Sl. No.

Name of the Student

Marks %

Title of the Project

Software Used

Name of the Guide

Name of the Institution

1

Sofia Munshi

79.2

Title : Computational Analysis of Microbial genome sequences.

Brief : This project aims at finding out the intra & inter genomic trends in the dinucleotide and trimicleotide patterns of usage in methanogenic(Archaea) and non – methanogenic(Proteobacteria) organisms. Multivariate analysis of M.flagellus & P.entomophila reveals that in both organisms the translational selection plays a major role in shaping the synonymous codon profiles & highly expressed genes preferable use the GC ending codons.

Clustal W, TreeView, NCBI.

Dr.Chitra Dutta

Indian Institute of Chemical Biology, Kolkata

2

Sarbani Chattopadhyay

75.9

Title : Study of DNA drug interaction using AUTODOCK.

Brief : This project aims at finding out the interaction pattern between Y-Oxapentamidine with d(CGCGAATTCGCG)2 as obtained from NDB. The global minima is detected by SIMULATED ANNEALING. Finally stability of such complex is studied.

AUTODOCK, AUTOGRID, PDB MOLDEN, GAMESS, CharmM.

Dr.Dhananjay Bhattacharya

Saha Institute of Nuclear Physics, Kolkata

3

Anindita Khan

69.3

Title : Intergenomic Variation of Staphylococcus species

Brief : This project aimed at analyzing 13 species of staphylococcus, gram positive bacteria through multivariate statistical analysis. The analysis revealed both similarities & divergences in the nature of selection forces shaping the genome/proteome composition of these organisons.

Codon- w, Statistica.

Dr.Santasabuj Das

NICED(ICMR). Kolkata

4

Patanjal Roy

69.2

Title : Identification of p53 protein’s response elements using weight matrix.

Brief : This project aims at studying the TP53 gene codes for P53 which is an antilumar protein. The putative binding element within a 2 Kb sequence of promoter region of P53 gene was identified & its potentiability was measured by Putative P53identifying algorithm.

GENBANK, GENECard.

Dr Keya Choudhuri

Indian Institute of Chemical Biology (IICB) Kolkata

5

Aparna Samal

67.0

Title : Sequence & structural analysis of human aquaporing using computational strategies.

Brief : This project aims at building a knowledge based model for human aquaporin 6(AQP 6) protein. The motif region of the protein was identified. Moreover a great degree of sequential similarly among aquaporions was reported revealing that these are evolutionary related.

Clustal W, Tree View, Swiss Model, Rasmol & Swiss PDB Viwer.

Mrs.Vaijyanthi Raghavan

Software Technology Group, Bangalore

6

Kriti Kayal

66.5

Title : Protein Modelling of Lanosterol synthase Rat.

Brief : “Lanosterol Synthase” protein’s role on Cataract led to this project which aimed at building the 3 dimensional structure of this protein with the help of Insight II. The homologues of this protein were identified & studied for building the three dimensional structure in this present study.

BLAST, FASTA, Clustal W, PROCHECK, INSIGHT II, GENBANK, EMBL, DDBJ, Swiss Prot, PIR, TREMBL.

Dr.Shyam Charan

GVK Biosciences, Hyderabad

7

Annapurna Behura

64.3

Title : Molecular Phylogenetic Analysis of Anophelines based on 28 S rDNA sequence.

Brief : This project aimed at studying the nucleotide sequence of ITSR region of 28S ribosomal DNA in order to construct the phylogeny of Anophelines. Cladistic approach is the best one for this study which demonstrated the utility of rDNA for evaluating phylogenetic & evolutionary relationships among various species of mosquito

Clustal W, GENBANK, DDBJ

Dr R.K. Hazra & Dr. N. Mohapatra

Regional Medial Research Centre (RMRC) Bhubaneswar

8

Pradyumna ku Sahoo

63.6

Title : Leukemia : A better lead design by binding free energy calculations.

Brief : Leukemia or blood cancer is a disease affecting WBCs. Among the various available drugs, Cladribine was selected & nine analogs were obtained by molecular modeling techniques. Then QSAR calculations & Monte Carlo simulation techniques were employed. On comparing these analogs, it was found that the analogue 2 with substituent CF3(R2)was the best one as it effectively blocks the activity of IMMUCILLIN – H and SULFATE.

Hyper Chem, GOLD, OpenEye, CharmM, Amber, GROMOS.

Mr.Manoj ku Reddy

Aravinda Biosolutions, Hyderabad

9

Amrita Dash

63.5

Title : AIDS : A better lead design by binding free energy calculations.

Brief : This project aims at performing computer aided drug design on camptothecin, a chemical to suppress HIV. 9 potent analogues were designed for camptothecin out of which the analogue number 8 with substituent CH3(R1) is identified as the most suitable analogue in the study.

Hyperchem, Openeye, Gold, CharmM, Amber, Gromos.

Mr.Manoj ku Reddy

Aravinda Biosolutions, Hyderabad

10

Amrit ku Senapati

59.4

Title : Diabetes II : A better lead design by binding free energy calculations.

Brief : This project aimed at finding out the analogues of acurea; a selective drug for diabetes II. Out of all the analogues, the analogues 4 & 5 with substituent CF2OH(R4) & CF3 (R5) were identified as the most suitable ones in the present study. The analogues were evaluated on energy simulation basis & QSAR calculations

Hyperchem, gold, Openeye, Amber, Bio + CharmM, PDB, Pfarm.

Mr.Manoj ku Reddy

Aravinda Biosolutions, Hyderabad.

11

Pradyumna Patra

Title : Parkinsons Disease : A Better lead design by binding free energy calculations.

Brief : This project aims at refining the dry Sinemet which is effective against Parkinsons disease. Out of the 9 analogues prepared, the analogue number 5 & 6 with substituents CN & CCL3 were identified as the most suitable ones in the present study.

HyperChem, PDB, GOLD, OpenEye, AMBER.

Mr Manoj Kr Reddy

Aravinda Bio Solutions Hyderabad